With receiving more and more attention, an increasing number of key proteins have been identified in ALL.8, 9, 10, 11 PAQR3 has been uncovered to be a critical regulator into various cancers.15, 16, 17, 18 In particular, researchers found PAQR3 affect leukemic cells proliferation and apoptosis,19 nevertheless, its role and relevant regulatory mechanism in ALL keeps unknown. The gene discussed is PAQR3; the disease is acute lymphoblastic leukemia.