PAQR3 and cancer: With receiving more and more attention, an increasing number of key proteins have been identified in ALL.8, 9, 10, 11 PAQR3 has been uncovered to be a critical regulator into various cancers.15, 16, 17, 18 In particular, researchers found PAQR3 affect leukemic cells proliferation and apoptosis,19 nevertheless, its role and relevant regulatory mechanism in ALL keeps unknown.