Thus, not only OPN3 is expressed and affects apoptosis in human epidermal melanocytes, but also OPN3 is linked to the metastasis and drug resistance in some types of lung tumors and liver cancer, respectively.15, 16, 17, 18, 19, 20 For these reasons, we sought to investigate the clinicopathologic data and OPN3 expression patterns for ALMs to determine any associations with prognosis. The gene discussed is OPN3; the disease is liver cancer.