For instance, miR‐146a can alleviate high glucose/thrombin‐induced endothelial inflammation in diabetic atherothrombosis via targeting NOX4 expression42; miR‐99a‐5p can restrain the proliferation, migration and invasion of oral carcinoma cells by targeting NOX4 expression17; miR‐423‐5p can attenuate high glucose‐induced podocyte injury in diabetic nephropathy by targeting NOX4 expression.18 The gene discussed is NOX4; the disease is lip and oral cavity carcinoma.