Consistent with the data in 3×Tg‐AD mice, the APP/PS1 mice treated with MN‐08 in the prevention study also experienced a reversal of the depressed expression of synapse‐related proteins, including synaptophysin (SYP), PSD95, synapsin I (SYN I), synapsin II (SYN II), and drebrin (Figure S3a,b). This evidence concerns the gene PSEN1 and Alzheimer disease.