Most studies into miR100 in lung diseases concern its antitumor effects and its role as a potential molecular prognostic marker in nonsmall lung cancer.44,45 Recently, miR100 has been demonstrated to modulate LPS-induced apoptosis and autophagy of WI-38 cells (normal human fibroblast cell line) through activating PI3K/protein kinase B/NF-κ-light-chain-enhancer of activated B cells (PI3K/AKT/NF-κB) intracellular pathway in the experimental model of acute pneumonia.46 The gene discussed is AKT1; the disease is lung disorder.