Over the past a few years, miR27a/b has been shown to have an important role in neovascularization and granulocyte differentiation, which enhances capillary sprouting and endothelial tip fate through inhibiting Notch signaling, the Delta-like ligand 4 and sprouty-2.37,38 Research has shown that miR27 is involved in attenuating acute liver inflammation and oxidative stress through decreasing the levels of TNF-α and IL-6, and elevating the production of superoxide dismutase and glutathione peroxidase via miR27-TAB3-NF-κB intracellular signaling pathways in the mouse model of sepsis.39 The gene discussed is NFKB1; the disease is Sepsis.