SKP2 and cancer: It has been illuminated that the miR30 family (including miR30a, b, c, d, e), as tumor inhibitors, possesses the ability to suppress epithelial-mesenchymal transition in cancer cells, and overexpression of miR30s is responsible for reducing pulmonary vascular hyperpermeability to postpone cancer proliferation and metastasis through targeting S-phase kinase-associated protein 2 directly.41