Taking both correlation and diagnostic value into consideration, we verified that HPSE, IFI27, LGALS3BP, CRYM, HBD, COL6A3, LAMB2, and IFITM3 were positively related to pan‐cancer stage and had potential value for pan‐cancer diagnosis and staging with a sensitivity of 60.9%, 59.1%, 56.5%, 57.8%, 54.3%, 55.2%, 55.2%, and 60.9%, and a specificity of 94.5%, 90.9%, 87.3%, 89.1%, 72.7%, 85.5%, 89.1%, and 94.5%, respectively. Here, HBD is linked to cancer.