Taking these results into intersection, we discovered that ARL2, FCGR2A, and KLHDC8B were negatively correlated with the advanced, metastatic pan‐cancer in comparison with healthy controls and they were essential for advanced, metastatic cancers diagnosis with a sensitivity of 59.2%, 61.8%, and 59.7%, and a specificity of 80%, 89.1%, and 83.6%, respectively. The gene discussed is KLHDC8B; the disease is metastatic malignant neoplasm.