DEGs mainly located in localized tumor educated platelets (PLXNB3, SAMD14, ALAS2, C4orf48, PARP10, EHBP1L1, DYSF, SSBP4, LRRC75A, CD69, RSL24D1, ZNF667, PPT1, IARS, and HERC3), DEGs mainly located in the metastatic tumor educated platelets (FCGR2A, KLHDC8B, DEFA3, IGFBP2, MAOB, ZNF346, ARL2, MMP1, KLHL35, CA1, RP11‐525A16.4, CTD‐2509G16.2, and MS4A1) and those found in both localized and metastatic tumor educated platelets (HPSE, IFI27, LGALS3BP, CRYM, WASF1, HBD, COL6A3, PRSS50, LAMB2, LTF, TPM2, TYMP, NELL2, SLC38A1, and IFITM3) were selected for further analysis. This evidence concerns the gene HPSE and metastatic neoplasm.