IFI27, CRYM, HBD, and IFITM3 in TEPs were positively related to the pan‐cancer stage and essential for diagnosing cancers with a sensitivity of 59.1%, 57.8%, 54.3%, and 60.9%, and a specificity of 90.9%, 89.1%, 72.7%, and 94.5%, respectively. This evidence concerns the gene HBD and cancer.