HPSE, IFI27, LGALS3BP, CRYM, WASF1, HBD, COL6A3, PRSS50, LAMB2, LTF, TPM2, TYMP, NELL2, SLC38A1, and IFITM3 were differentially expressed in both localized and metastatic cancer educated platelets as compared to the platelets of healthy controls. The gene discussed is PRSS50; the disease is metastatic malignant neoplasm.