HPSE, IFI27, LGALS3BP, CRYM, WASF1, HBD, COL6A3, PRSS50, LAMB2, LTF, TPM2, TYMP, NELL2, SLC38A1, and IFITM3 were differentially expressed in both localized and metastatic cancer educated platelets as compared to the platelets of healthy controls. This evidence concerns the gene HPSE and metastatic malignant neoplasm.