In univariate Cox regression analysis, high nuclear grading (HR = 1.95, p = 0.001), unfavorable tumor architecture (HR = 2.69, p = 0.001), high average mitotic count (HR = 1.12, p = 0.003), and BAP1 tumor positivity (HR = 1.80, p = 0.030) were associated with shorter survival (see Table 1 in supplementary material, File S3). The gene discussed is BAP1; the disease is neoplasm.