Therefore, to test our hypothesis, we subjected Otsuka Long‐Evans Tokushima Fatty (OLETF) rats with type 2 diabetes to resistance exercises for 8 weeks and evaluated the effects of resistance exercise‐induced changes in musclin on the insulin resistance index via the muscle Akt/GLUT‐4 regulated signaling pathway. The gene discussed is OSTN; the disease is type 2 diabetes mellitus.