Tetraspanins are believed to regulate subcellular localizations and coordinate functions of their interactive partners including cell adhesion proteins, cell surface receptors, proteases and intercellular signalling molecules, thereby engaging in diverse molecular and cellular processes ranging from cell adhesion, migration, invasion, signalling, cell–cell fusion, infection by cancer‐causing viruses, morphology to survival during multiple stages of cancer development [16]. The gene discussed is CD177; the disease is cancer.