Tspan5 correlation analyses of TCGA tumour samples revealed that Tspan5 expression is positively correlated with the expression of ADAM10, Notch1, Notch2, Notch3, Notch4, Hey1, vimentin, N‐cadherin and Snail, whereas it is negatively correlated with E‐cadherin in HCC tissues (Fig. 6B). The gene discussed is NOTCH4; the disease is hepatocellular carcinoma.