The suppressive effects of 2 and 7 on HIF‐1α‐mediated gene transcription were investigated based on changes in the mRNA levels of the HIF‐1α downstream targets VEGF, glucose transporter‐1 (Glut1), and erythropoietin (EPO), which are crucial for tumor progression and angiogenesis.31, 32. This evidence concerns the gene SLC2A1 and neoplasm.