HIF1A and cancer: This heterodimer, known as HIF‐1, acts as a key regulator of O2 homeostasis and allows cancer cells to adapt to hypoxic conditions by the transcriptional activation of downstream genes that regulate glucose metabolism (glucose transporters), angiogenesis [vascular endothelial growth factor (VEGF)], cell proliferation [erythropoietin, insulin‐like growth factor 2(IGF‐2)], and cell survival (galectin‐3, VEGF‐A, Akt).5, 6