The suppressive effects of 2 and 7 on HIF‐1α‐mediated gene transcription were investigated based on changes in the mRNA levels of the HIF‐1α downstream targets VEGF, glucose transporter‐1 (Glut1), and erythropoietin (EPO), which are crucial for tumor progression and angiogenesis.31, 32. The gene discussed is EPO; the disease is neoplasm.