Several reviews and meta‐analyses of cytokines in GCF in otherwise healthy patients with periodontitis report that cytokines such as IL‐1α, IL‐1β, interleukin‐6 (IL‐6), GMCSF (granulocyte macrophage colony stimulating factor), interleukin‐12p40 (IL‐12p40), interleukin‐17 (IL‐17), TNF‐α, monocyte chemoattractant protein (MCP1/CCL2), matrix metalloproteases, bone remodeling products, prostaglandins, and macroglobulins are increased in periodontitis.4, 5, 6, 10, 11, 12, 13. This evidence concerns the gene IL1A and periodontitis.