To elucidate the relationship among circTLK1, miR-495-3p, and CBL in RCC cells, Caki-1 and 786-O cells were transfected with si-NC, si-circTLK1, si-circTLK1 + miR-NC inhibitor, or si-circTLK1 + miR-495-3p inhibitor. This evidence concerns the gene CBL and renal cell carcinoma.