APC and brain neoplasm: For example, the incidence of desmoid tumors, osteoma, and epidermoid cysts is significantly higher in individuals carrying mutations in APC codons 1395–1493 than in individuals with mutations in codons 177–452, and the development of hepatoblastoma and/or brain tumors occurs when the pathogenic variant is located only in codons 457–1309 [25, 36, 38, 39].