MGMT and neoplasm: Univariate Cox regression revealed prognostic values of CD86 expression, age, tumor grade, as well as molecular subtypes including IDH mutation status, X1p/19q codeletion, and MGMT methylation (Figure 7A); whereas, multivariate Cox regression showed independent prognostic roles of CD86 expression, age, tumor grade, and IDH mutation status in overall survival of LGG (Figure 7B).