This conclusion was supported by Wettstein et al. (2020) who provided evidence that alpha-1 antitrypsin (α1-AT) inhibits SARS-CoV-2 (virulent isolate and pseudoparticles) infection through targeting the viral spike protein and then blocks the SARS-CoV-2 infection of human airway epithelium at physiological concentrations (Wettstein et al., 2020). The gene discussed is SERPINA1; the disease is infection.