However, it should be noted that PF-4, LF, IL-8 (CXCL8), and polyarginine neutralize the anticoagulant activity of heparin (Shute et al., 2018), particularly in COVID-19 patients associated with thrombocytopenia and LF and IL-8 upregulation. This evidence concerns the gene CXCL8 and Thrombocytopenia.