RT-qPCR verification results showed that Helicobacter pylori CagA caused up-regulation of <i>BPTF, caspase3, CDH1, CTNNB1, and POLR2A</i> expression.<h4>Conclusion</h4>The current comprehensive analysis provides new insights for exploring the effect of CagA in human gastric cancer, which could help us understand the molecular mechanism underlying the occurrence and development of gastric cancer caused by <i>Helicobacter pylori</i>. The gene discussed is CDH1; the disease is gastric cancer.