Per the Infectious Diseases Society of America (IDSA) 2016 clinical practice guidelines for HIV patients with a CD4+ T-lymphocyte count <250 cells/mL with coccidioidomycosis, the treatment recommendation is antifungal therapy until the count is above 250 cells/mL whether the patient is immunocompetent or not. Here, CD4 is linked to coccidioidomycosis.