FOXM1 has also a transcriptional inhibitory effect on CDKN1A. FOXM1 has been described as a promoter of cell proliferation in a variety of tumors [29], and FOXM1 content was shown to be downregulated in breast and pancreatic cancer cell lines following PL exposure [30]. The gene discussed is CDKN1A; the disease is familial pancreatic carcinoma.