Very recently, Liang et.al reported that miR-124 expressions were decreased in CAD patients and atherosclerotic ApoE−/− mouse models, while the mimic expression of miR-124 remarkably reduced anti-inflammatory cytokines and proinflammatory cytokines and inhibited macrophage apoptosis through the suppression of p38, suggesting that overexpression of miR-124 may be considered a promising treatment for atherosclerosis and CAD patients [63]. Here, APOE is linked to coronary artery disorder.