NOX4 and cardiac hypertrophy: The NOX4 isozyme, expressed in the mitochondria of cardiomyocytes, is particularly important in this context as has been shown in an experimental study; in heart-specific NOX4 knock-out mice, cardiac hypertrophy, interstitial fibrosis, mitochondrial dysfunction, and apoptosis of cardiomyocytes following pressure overload are significantly prevented compared to that in wild-type mice [32].