NOX1 and Parkinson disease: In another study of a 6-hydroxydopamine-based model of PD neurodegeneration in rats, increased expression levels of NOX1 and Rac1 (a component of the NOX1 complex) have been observed in dopaminergic neurons of the substantia nigra along with oxidative DNA damage and neuronal death which could be prevented significantly by knocking down the expression of NOX1 [110].