CYBB and Cognitive impairment: On the other hand, transgenic mice (Tg2576) carrying human APP with the Swedish mutation and lacking in the catalytic subunit of NOX2 fail to develop oxidative damage, neurovascular dysfunction, and cognitive deficits at 12-15 months of age unlike Tg2576 mice with intact NOX2, though the brain amyloid beta burden in both the groups were similar [141].