In the same study, high levels of NOX2 in reactive microglia associated with dopaminergic neuronal loss have been observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced experimental models of PD, and interestingly, much less dopaminergic neuronal loss is noticed in mice lacking NOX2 suggesting a clear link between neuronal death and NOX2 activation [109]. This evidence concerns the gene CYBB and Parkinson disease.