For example, diet-induced obesity and insulin resistance potentially impair endometrial stromal cell decidualization in mice in early stage pregnancy [31], insulin resistance during postimplantation period impairs mice uterine morphology, decidualization, and placentation processes [29], and overfeeding prior to parturition in dairy cows impaired insulin sensitivity and that negatively affected fertility [30]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.