NRF-2 also regulates proteostasis [7], neuroinflammation [8], neurogenesis [9], and bioenergetic homeostasis [10] in the central nervous system and activates NRF-2-dependent genes and enzymes, which confer neuroprotective effects in neurodegenerative diseases [11, 12]. The gene discussed is NFE2L2; the disease is neurodegenerative disease.