Considering the potential functional significance of polymorphisms in genes encoding the Nrf2 transcriptional factor, as well as antioxidant SOD2, GPX1, and detoxification GSTP1 enzymes in both the onset and prognosis of clear cell RCC, the aim of this study was to evaluate the effect of specific Nrf2, SOD2, and GPX1 gene variants and GSTP1ABCD haplotype on the risk, development, and postoperative prognosis in patients with ccRCC. This evidence concerns the gene GSTP1 and nonpapillary renal cell carcinoma.