Based on the established role of the GSTPi class in inhibition of JNK1 and its antiapoptotic effect [17, 45], we assessed the expression of GSTP1 and expression of regulatory (JNK1/2) and executor (caspase-3) apoptotic molecules in human ccRCC tissue samples, as well as the presence GSTP1 : JNK1/2 protein : protein interactions, however irrespective of the GSTP1 genotype. The gene discussed is CASP3; the disease is nonpapillary renal cell carcinoma.