Serum IL-37 increases in patients with poor outcome, and an IL-37 in the highest quartile is related to poor outcome (OR = 4.85; 95%CI = 3.11 - 8.22; <i>P</i> < 0.001).<h4>Conclusion</h4>Serum IL-37 increased in patients after ischemic stroke and was associated with stroke recurrence events and poor stroke outcomes. This evidence concerns the gene IL37 and stroke disorder.