OPTN and amyotrophic lateral sclerosis: OPTN is known as an NF-κB basic regulation-related protein and is involved in maintaining the morphology of the Golgi apparatus and in regulating exocytosis, endoplasmic reticulum stress, membrane receptor levels, type-I interferon response, cell death, and autophagy; nonsense and missense mutations of the OPTN gene abolish the inhibitory effect of NF-κB activation, and NF-κB inhibitors can be used to treat ALS [6, 13].