Although these four genes (SYNRG, ITSN2, PICALM, and AP3B1) have not been reported in the literature on ALS, the SYNRG, ITSN2, PICALM, AP3B1, and AAK1 genes are regulated by MALAT1, and the proteins encoded by these genes are all related to clathrin. The gene discussed is ITSN2; the disease is amyotrophic lateral sclerosis.