Notably, it has been reported that some genes regulated by MALAT1 are involved in the pathogenesis of ALS, including DECR1 [26], CPEB4 [27], VPS37A [28], SP1 [10, 29], EEA1 [30], RB1 [31], and GCLC [32] (Figure 4(a)). The gene discussed is SP1; the disease is amyotrophic lateral sclerosis.