HNRNPA2B1 and amyotrophic lateral sclerosis: Martinez et al. found that hnRNPA2/B1 D290V mutant fibroblasts and motor neurons differentiated from induced pluripotent stem cells obtained from ALS patients showed abnormal splicing changes and that the survival rates of induced pluripotent stem cell with mutations were decreased in long-term culture, which aggravated changes in gene expression and splicing, when placing stress on the cells [38].