Although these four genes (SYNRG, ITSN2, PICALM, and AP3B1) have not been reported in the literature on ALS, the SYNRG, ITSN2, PICALM, AP3B1, and AAK1 genes are regulated by MALAT1, and the proteins encoded by these genes are all related to clathrin. This evidence concerns the gene SYNRG and amyotrophic lateral sclerosis.