Therefore, we speculate that the TNF signaling pathway, toll-like receptor signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, NF-kappa B signaling pathway, and VEGF signaling pathway may be the important pathways to exert their synergistic effects against cerebral ischemia injury. The gene discussed is AKT1; the disease is Cerebral ischemia.