By comparing the research results with known experimental results, it was concluded that CRP-PR herb pair treat diseases by mediating the biological processes such as tumor signaling pathway, PI3K-Akt signaling pathway, MAPK, and others to regulate the proliferation, apoptosis, metastasis, and vascular regeneration of GC cells, reflecting the synergistic effect of Chinese medicine from multiple components, multiple targets, and multiple pathways, which will lay a solid foundation for further elucidation of its action mechanism. This evidence concerns the gene AKT1 and neoplasm.