Thus, we speculated that the abundant bioactive ingredients of Gegen may work simultaneously on multiple targets in the PI3K-Akt signaling pathway, AGE-RAGE signaling pathway, fluid shear stress, and atherosclerosis to exert a synergistic therapeutic effect on T2DM and hyperlipidemia, which not only regulates glucose and lipid metabolism directly but also prevents and improves complications secondary to glucose and lipid metabolic disorders. Here, AKT1 is linked to type 2 diabetes mellitus.