The top three targets with the highest degree value in the network were AKR1B1 (degree = 13, BC = 0.0219, and CC = 0.5000), EGFR (degree = 13, BC = 0.0202, and CC = 0.5000), and ESR1 (degree = 13, BC = 0.0188, and CC = 0.5000), suggesting that they are crucial genes involved in the effect of Gegen on targeting T2DM with hyperlipidemia, and TNF, NOS3, MAPK3, PPAR-γ, PPAR-α, ESR2, CYP19A1, INS, IL6, and SORD are also relatively important targets (see Supplementary Material 4 for more topological parameters). The gene discussed is ESR2; the disease is type 2 diabetes mellitus.