These pathways are the PI3K-Akt signaling pathway (degree = 14), AGE-RAGE signaling pathway (degree = 11), fluid shear stress and atherosclerosis (degree = 11), endocrine resistance (degree = 9), HIF-1 signaling pathway (degree = 9), PPAR signaling pathway (degree = 8), insulin resistance (degree = 8), TNF signaling pathway (degree = 8), nonalcoholic fatty liver disease (degree = 8), prolactin signaling pathway (degree = 6), type II diabetes mellitus (degree = 5), and ovarian steroidogenesis (degree = 5), and much more information is available in Supplementary Material 4. The gene discussed is RENBP; the disease is Insulin resistance.