According to a previous study, ESR1-knockout female mice exhibited significant weight gain, obviously higher fasting blood glucose and lipid levels, elevated levels of circulating and tissue inflammatory markers (PAI-1, MAPK8, and TNF), increased muscular lipid accumulation, impaired glucose tolerance, and insulin resistance, even when they were fed a normal chow diet [46]. The gene discussed is ESR1; the disease is Impaired glucose tolerance.