On the other hand and more importantly, it also regulates the expression of proteins that mediate complications and risk factors for diabetes and hyperlipidemia, including diabetic cataracts, diabetic retinopathy, diabetic neuropathies, inflammation, atherosclerosis, liver steatosis, and obesity (AKR1B1, SORD, TNF, NOS3, IL6, EGFR, ESR1, and ESR2), to alleviate pathological progression and improve the prognosis. The gene discussed is AKR1B1; the disease is diabetic neuropathy.