On the other hand and more importantly, it also regulates the expression of proteins that mediate complications and risk factors for diabetes and hyperlipidemia, including diabetic cataracts, diabetic retinopathy, diabetic neuropathies, inflammation, atherosclerosis, liver steatosis, and obesity (AKR1B1, SORD, TNF, NOS3, IL6, EGFR, ESR1, and ESR2), to alleviate pathological progression and improve the prognosis. This evidence concerns the gene ESR2 and diabetic retinopathy.