AKT1 and atherosclerosis: Thus, we speculated that the abundant bioactive ingredients of Gegen may work simultaneously on multiple targets in the PI3K-Akt signaling pathway, AGE-RAGE signaling pathway, fluid shear stress, and atherosclerosis to exert a synergistic therapeutic effect on T2DM and hyperlipidemia, which not only regulates glucose and lipid metabolism directly but also prevents and improves complications secondary to glucose and lipid metabolic disorders.