PTEN and osteosarcoma: Previous studies have reported that miR-130a could facilitate proliferation and metastasis of tumor cells through downregulating the expression of tumor suppressor genes, such as phosphatase and tensin homolog (PTEN) in osteosarcoma and breast cancer [25, 33], peroxisome proliferator-activated receptor gamma (PPARG) in chorangiocarcinoma [34], and collapsing-response mediator protein type 4 (CRMP4) in gastric cancer [35].