CD8A and type 1 diabetes mellitus: In regard to HLA class I epitopes, spliced peptides, generated in the proteasome through a process referred to as transpeptidation by which two different regions of a protein or of two different proteins are fused (57, 58), have been identified in a human beta-cell line by HLA-peptidomics (21, 25) and were recognized by circulating and pancreas-infiltrating CD8+ T-cells from T1D donors.