Co-occurring of genetic mutations in cancers with KDM5C alterations were not uncommon in both early-stage and advanced stage cohort (Figures 4C, D) and some of them are prevalent driver genes (e.g., LRP2, KMT2C, PBRM1, NOTCH1, FAT1, SETD2, NSD1, etc.), while their clinical significance remained undetermined. This evidence concerns the gene PBRM1 and cancer.