Interestingly, we found a positive association between co-occurrence of KDM5C alterations and some common epigenetic regulatory genes including PBRM1, KMT2C, SETD2, NSD1, etc. In spite of the unclear biological function of these co-mutations, several previous studies have shown that these diver genes are very important tumor suppressor genes in renal cell cancers and could contribute to the aggressive phenotype, therapeutic efficacy and/or prognostic value (23–29). This evidence concerns the gene NSD1 and renal cell adenocarcinoma.