Tumor suppressormiR-146a knockout mice spontaneously develop B cell lymphomas and myeloid malignancies (71, 72). miR-146b and miR-146a knockout mice develop histologically distinct B cell lymphomas (73). miR-146a deficiency accelerates c-MYC-induced B cell lymphoma development (74). Here, MYC is linked to B-cell non-Hodgkin lymphoma.