Immunosuppressive roles in innate and adaptive immunity (72, 75). Downregulates the expression of signaling pathway components involved in GC B-Tfh cellular interactions, such as ICOSL-ICOS (34) and CD40-CD40L (35). Limits Tfh numbers by downregulating Stat1 expression (75) and counterregulates miR-155 targets in Tfh cells, which is relevant to inhibit the generation of autoantibodies associated to age-dependent inflammation (52). Dysregulated overexpression promotes a lymphoproliferative syndrome and GC B cell expansion via Fas expression downregulation in GC B cells (76). The gene discussed is ICOS; the disease is lymphoproliferative syndrome.