CR2 and infection: As ECs are negative for the EBV CD21/CR2 receptor employed by EBV to infect B cells and T-cells (63–65), we used monocytes bound to recombinant EBV/p2089 (EBV/p2089 loaded monocytes) as the vehicle to infect human dermal primary microvascular endothelial cells (HDMECs) (EBV-monocyte transfer-infection) (55, 66, 67), as previously shown in fibroblasts (41).