Interestingly, genes which were previously identified as markers of vascular dysfunction in SSc, such as EDN1, thrombospondin 1 (THBS1), and heparan sulfate proteoglycan 2 (HSPG2) (46, 72, 73) were also induced by EBV in infected endothelial cells (Figures 7F–H). This evidence concerns the gene HSPG2 and systemic sclerosis.