BMPR2 and pulmonary arterial hypertension: A central role for the vasculature in these processes was reinforced by a recent study, in which schistosome infected mice with heterozygous deletion of Bmrp2 (bone morphogenetic protein type-II receptor, BMPR-II), the most common genetic cause of pulmonary arterial hypertension (PAH), had enhanced pulmonary egg deposition.