In the current study, we examined the pyroptosis signaling pathway as a target of exenatide by examining the expression levels of the pyroptosis-related factors, NLRP3, caspase-1, GSDMD, and IL-1β in oleic acid- and MCD diet-induced in vitro and in vivo models of NASH, respectively. Here, CASP1 is linked to metabolic dysfunction-associated steatohepatitis.