Other authors, including Oldfield E.H and Newell-Price J., suggest that BIPSS should be performed in most patients with ACTH-dependent CS, because the results of biochemical tests with CD and EAS may overlap (some neuroendocrine tumors may express glucocorticoids and/or CRH and/or vasopressin receptors). This evidence concerns the gene POMC and Cowden syndrome 1.