POMC and Anorexia: These results support the hypothesis that changes in affinity of autoantibodies reacting with α-MSH and ACTH are involved in the pathogenesis of AN and BN and that increased levels of high-affinity anti-α-MSH or anti-ClpB (α-MSH conformational mimetic produced by Enterobacteriaceae) autoantibodies can induce bulimia, while increased levels of low-affinity anti-α-MSH autoantibodies can induce anorexia (24, 110, 112) (Table 1).