More importantly, emerging research reported that naringin attenuated the severity of colitis by suppressing endoplasmic reticulum stress-induced autophagy in colorectal mucosal cells (Pei et al., 2020), and regulated autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress (Wang et al., 2020), or decrease hepatic stellate cell activity in liver fibrosis (Shi et al., 2016), the same as the autophagy regulatory pathway of NSAIDs intestinal disease in this study. This evidence concerns the gene AKT1 and intestinal disorder.