While it has been suggested that AMD pathogenesis can be differentiated by gender [14], we performed the SNP analysis in males and females separately and found that IL-9 rs11741137 (CC, CT, and TT), IL-9 rs2069885 (GG, GA, and AA), and IL-9 rs2069884 (GG, GT, and TT) genotypes were distributed statistically significantly between males with early AMD and control males: 73.3%, 20%, and 6.7 vs. 66.4%, 31.5%, and 2%, p = 0.032; 73.3%, 20%, and 6.7 vs. 67.1%, 30.9%, and 2%, p = 0.039; 73.3%, 20%, and 6.7 vs. 67.1%, 30.9%, and 2%, p = 0.039, respectively (Table 4). The gene discussed is IL9; the disease is age-related macular degeneration.