Binomial logistic regression analysis revealed that IL-9 rs1859430 GA genotype was associated with 46 and 48% decreased odds of early AMD in males under the codominant and overdominant genetic models (OR = 0.547; CI: 0.302-0.991; p = 0.047 and OR = 0.526; CI: 0.292-0.948; p = 0.033, respectively). The gene discussed is IL9; the disease is age-related macular degeneration.