SPP1 and Hepatic fibrosis: Additionally, APOA1 acts as a hub linking other fibrosis-related proteins in this network analysis (n = 16, 0.740 < score < 0.999; Fig. 3B), such as alpha-2-macroglobulin (A2M), apolipoprotein C-I (APOC1), fibrinogen gamma chain (FGG), haptoglobin (HP), hemopexin (HPX), and osteopontin (SPP1), most of which are activated in hepatic fibrosis.