NCT04277442 is a phase I trial combining nivolumab with decitabine and venetoclax in frontline TP53-mutated AML, NCT02397720 is evaluating nivolumab with azacitidine and venetoclax in R/R and frontline AML, and NCT04284787 is a phase II trial of pembrolizumab in combination with azacitidine and venetoclax in newly diagnosed AML patients deemed unsuitable for induction therapy. Here, TP53 is linked to acute myeloid leukemia.