The evidence shows that in STZ-induced diabetes, myostatin/protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) and forkhead box protein O1 (FoxO1) signaling pathway downregulates the expression of glucose transporter 4 (GLUT4) and induces skeletal muscle atrophy36. This evidence concerns the gene SLC2A4 and diabetes mellitus.