CLDN1 and liver cancer: Among those genes, CLDN1, ITGA6  and  ID2 have been reported to promote EMT, cell migration and proliferation in liver cancer cells39–41, and the resminostat/sorafenib drug combination reduced the mRNA level of these genes (significantly for CLDN1 p = 0.0008, ITGA6 p = 0.0009).