EPCAM and breast cancer: Precision-Recall Curves (PRC) showed that CA 15-3 and EpCAM on EVs achieved a high discriminative capacity to differentiate BC from HD (area under the PRC (AUPRC) = 0.9286 for CA 15-3; AUPRC = 0.9709 for EpCAM; Fig. 2d, e and Supplementary Table 5).