ERBB2 and breast cancer: The EVDX signature, representing a weighted sum of CA 15-3, CA 125, CEA, HER2, EGFR, PSMA, EpCAM, and VEGF signals identified by linear discriminant analysis (LDA, Supplementary Software), had remarkably high accuracy (AUPRC = 0.9912) to distinguish BC from HD, and an AUPRC of 0.9433 for MBC and NMBC classification (Fig. 3a, b and Supplementary Table 5).