NFKB1 and Increased total eosinophil count: CD200R engagement inhibits both the canonical and non-canonical NF-κB pathways in activated pulmonary ILC2s, as evidenced by downregulation of pIKKα/β, Nfkb1, and Rela (p65), as well as Nfkb2 (p52) and Relb. Utilizing CD200-Fc (CD200-Fc chimeric protein), we demonstrate the preventative and therapeutic role for CD200R engagement on ILC2s, resulting in reduced airway resistance, dampened eosinophilia, and improved lung dynamic compliance.