EGFR and lung cancer: The major pathways associated with lung cancer were enriched with good coverage, including ErbB signaling (921 phosphosites, 800 class 1 on 65 proteins, 78%), NSCLC signaling (568 sites, 471 class 1 from 52 proteins, 79%), and the EGFR-TKI resistance pathway (743 sites, 648 class 1 from 59 proteins, 76%) and endocytosis (2080 sites, 1732 class 1 from 193 proteins, 80%) (Fig. 3d).