EGFR and non-small cell lung carcinoma: Pathway analysis of upregulated phosphoproteins against KEGG database enriched the top ranking pathways, including NSCLC signaling, ErbB signaling, Ras signaling, endocytosis, and the EGFR-TKI resistance pathway, which have been reported to be associated with TKI resistance in NSCLC (Fig. 5c).