To assess the role of Ambra1 in Braf/Pten-driven melanoma, Ambra1flox/flox mice16 were crossed with mice carrying BrafV600E mutation and Pten deletion (BrafV600E/+;Ptenflox/flox)15, a genetic combination that induces melanoma with 100% penetrance in mice17,18. The gene discussed is AMBRA1; the disease is melanoma.