Intriguingly, when we expressed the FAK1P876A/P882A mutant (HA-FAK1.miResAA)—previously reported to abrogate the interaction with AMBRA120— in FAK1 depleted SK-Mel-5 melanoma cells (siFAK1), we observed a reduction in AMBRA1/FAK1 interaction (Supplementary Fig. 5l). The gene discussed is AMBRA1; the disease is melanoma.