Despite its heterogeneity, which is largely due to its high mutational burden, alterations of key genes of the mitogen-activated protein pinase (MAPK) and the phosphatidylinositol-3-kinase/AKT serine/threonine kinase 1 (PI3K/AKT) pathways have been identified as hallmarks of melanoma and have contributed to improve patient stratification1,2. Here, AKT1 is linked to melanoma.