In fact, while autophagy flux was affected in AMBRA1-silenced cells (Supplementary Fig. 6j, k), bulk autophagy was not altered in Ambra1-null Braf-mutated melanocytes (Supplementary Fig. 2f, j) and melanomas (Supplementary Fig. 6l, m), thus implying compensatory events taking place in the tumor. The gene discussed is BRAF; the disease is melanoma.