Considering that we observed: (i) increased hyperpigmentation in the murine skin of mice with BrafV600E background, and (ii) large-sized and early tumors in Braf/Pten-driven mouse models of melanoma upon Ambra1 deficiency, we investigated and related the proliferative advantage of Ambra1-deficient melanocytes and melanoma to both c-Myc and Cyclin D1. Here, BRAF is linked to melanoma.