WB analyses revealed a marked increase of the phospho-active forms of FAK1 (pFAK-Y397 and -Y576) and SRC (pSRC-Y416) in BPA−/− tumors (Fig. 5a and Supplementary Fig. 5a) and in human melanoma cells silenced for AMBRA1 (Fig. 5b and Supplementary Fig. 5b–d), as well as in iLN metastasis of BPA−/− (Supplementary Fig. 5e) and in melanocytic nevi of BA−/− mice (Supplementary Fig. 2f, i). The gene discussed is AMBRA1; the disease is melanoma.