However, cancer cells have developed various strategies to escape recognition and attack by NK cells during metastasis, including the following: (i) modification of NK cell-activating ligands and NK cell inhibitory ligands47–49; (ii) recruitment of immunosuppressive cells, such as classical CD11b+Ly6G+ neutrophils, Treg cells, and platelets50–52; and (iii) secretion of immunosuppressive factors, such as transforming growth factor-β and IL-1053–55. The gene discussed is ITGAM; the disease is cancer.