In addition, in vitro functional validation assays found that circRNA_102481 silencing inhibited EGFR-TKIs-resistant NSCLC cell proliferation and promoted apoptosis, circRNA_102481 overexpression could promoted EGFR-TKIs sensitive NSCLC cell proliferation and inhibited cell apoptosis which suggested that circRNA_102481 can contribute to EGFR-TKIs resistance in NSCLC. Here, EGFR is linked to non-small cell lung carcinoma.