However, in PC9/GR and HCC827/ER cells, the ROR1 mRNA and protein expression levels in exosomes were significantly lower than those in cells (Figure 12C, 12D; p<0.05), indicating that ROR1 mRNA and protein is not secreted in the form of exosomes by PC9/GR and HCC827/ER cells to the tumor microenvironment. This evidence concerns the gene ROR1 and neoplasm.