PPM1D, a member of the PP2C family that is recognized as a common oncogene, is related to many different human tumors, including adult supratentorial diffuse astrocytoma and oligodendroglioma, high-grade glioma [7], non-small-cell lung cancer [8] and lymph node metastasis, as well as esophageal squamous cell carcinoma (ESCC) [9]. This evidence concerns the gene PPM1D and esophageal squamous cell carcinoma.